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Acs Chemical Neuroscience 2014, Vol. 5 (9) :752 -75217 doi:10.1021/cn500143n <<-上一篇 下一篇 ->>
Advances in Therapeutics for Neurodegenerative Tauopathies: Moving;toward the Specific Targeting of the Most Toxic Tau Species
Gerson, Julia E.;Castillo-Carranza, Diana L.;Kayed, Rakez
[Gerson, Julia E.; Castillo-Carranza, Diana L.; Kayed, Rakez] Univ Texas Med Branch, Dept Neurol, George & Cynthia Mitchell Ctr Alzheimers Dis Res, Galveston, TX 77555 USA.
Abstract: Neurodegenerative disease is one of the greatest health concerns today and with no effective treatment in sight, it is crucial that researchers find a safe and successful therapeutic. While neurofibrillary tangles are considered the primary tauopathy hallmark, more evidence continues to come to light to suggest that soluble, intermediate tau aggregates tau oligomers-are the most toxic species in disease. These intermediate tau species may also be responsible for the spread of pathology, suggesting that oligomeric tau may be the best therapeutic target. Here, we summarize results for the modulation of tau by molecular chaperones, small molecules and aggregation inhibitors, post-translational modifications, immunotherapy, other techniques, and future directions.
Keywords: PAIRED HELICAL FILAMENTS NUCLEATED CONFORMATIONAL CONVERSION MICROTUBULE-STABILIZING AGENT FIBRILLIZATION IN-VITRO AMYLOID-BETA PEPTIDES HEAT-SHOCK PROTEINS DISEASE MOUSE MODEL FULL-LENGTH TAU ALZHEIMERS-DISEASE A-BETA
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