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Biochimie 2009, Vol. 91 (1) :52 -57 doi:10.1016/j.biochi.2008.05.021 <<-上一篇 下一篇 ->>
Twenty-five years of research on bovine lactoferrin applications
Abstract:

Lactoferrin (LF) was identified as a milk protein in 1960. Large-scale manufacturing of bovine LF (bLF) was established more than 20 years ago. Using this commercially available material, research for bLF applications has advanced from basic studies to clinical studies, and bLF has been applied to commercial food products for the last 25 years. During this period, it was found that LF is digested by gastric pepsin to generate a multi-potent peptide, lactoferricin. It was also demonstrated that oral administration of bLF augments host protection against infections via antimicrobial action and immunomodulation of the host. In addition, researchers have demonstrated that oral administration of bLF prevents cancer development. In this review, we look back on 25 years of bLF research and development.

Keywords: Bovine Lactoferricin Lactoferrin
收稿日期:15 January 2008     发布日期: 10 June 2008    
Deduced mechanism of action underlying the host-protective effects of orally administered bLF. After ingestion, bLF is partially digested to peptides by proteases in the stomach and intestine. In the small intestine, bLF and its digested peptides bind to receptors on enterocytes and immune cells such as dendritic cells and lymphocytes residing in the intestinal epithelium. bLF/peptides may be internalized into the cells and/or trigger intracellular signaling to activate transcription of genes. Humoral factors like cytokines are secreted from these cells by bLF/peptides stimulation and reach diseased sites through the circulation. Otherwise, the stimulated immune cells in the intestine migrate to diseased sites. These humoral factors and immune cells then act to improve infection and inflammation symptoms, and to prevent carcinogenesis.
Amino acid sequences of lactoferricin (LFcin) H and B. Basic amino acids are represented by circles. Modified from [54]. LFcin H and B are 47 and 25 amino acid peptides derived from the homologous N-terminal region of hLF and bLF, respectively, by pepsin digestion.
Table 1.Twenty-five years of LF research and development worldwide
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